Sodium gluconate-Comparison of biological fermentation method and chemical method production
Through microbial cultivation, glucose oxidase is produced, which oxidizes the substrate glucose into gluconic acid. Through continuous flow of caustic soda, pH is controlled and gluconic acid is neutralized to produce the required product sodium gluconate.
Through carbon-palladium and other rare metals catalyzed reaction, the substrate glucose is oxidized to gluconic acid, and caustic soda is continuously added to control the pH and neutralize the gluconic acid to generate the required product sodium gluconate.
Fermentation tank, air compressor and air sterilization system
Reactor, air compressor
Pros and cons
The biological culture method produces gluconate oxidase, with low culture cost, reproducibility, low reaction temperature, stable production, and easy to form large-scale production;
Fermentation production is an aseptic operation and requires a high level of management.
Heavy metal catalyzed reaction, expensive, easy to deactivate after continuous use, and heavy metal pollution;
The reactor structure of the production equipment is simple, suitable for small-scale production
Step two (extraction)
The extraction method of the above two methods is the same, but the domestic chemical production is small-scale, the process design is simple, the relative level is not high, the product appearance, and the yield is low; while the fermentation method has a larger production scale, and the process design absorbs the same industry Achievements, the adoption rate of new equipment is high, the overall level is high, the appearance of the finished product is good, the physical and chemical indicators are stable and low, and the development speed is fast.
Combining the above two production technologies, each has its advantages and its own reasons for existence and development. Today, with continuous technological advancement, they can find their own development positions.
Introduction to the production process of sodium gluconate
Sodium gluconate manufacturers technology sharing: introduction to the production process of sodium gluconate
Sodium gluconate is a deep-processed product of glucose, and it is also the basic raw material of gluconolactone, gluconate (zinc, copper, ferrous salt), etc., and has a wide range of nutritional supplements, food preservatives, food improvers, and pharmaceutical raw materials. At the same time, due to its excellent chelating properties, it is widely used in the preparation of metal surface treatment agents, various cleaning agents, water quality stabilizers, etc.; in addition, it is also used as the most advanced building water reducer, electroplating Liquid components and so on. With the continuous expansion of application fields, the demand for sodium gluconate in my country has increased year by year, and the production capacity of a single device has now exceeded 3000 t/a.
Sodium gluconate production processes include fermentation, catalytic oxidation, electrolysis, etc., among them, fermentation is a classic production method, which uses Aspergillus niger to convert glucose into gluconic acid, and then neutralizes the production of sodium gluconate by adding alkali. This method requires a high degree of sterilization and a long fermentation period, which keeps the cost high, and the current output has decreased year by year; the catalytic oxidation method uses a specially treated Pd/C catalyst to oxidize the glucose solution, which has less equipment investment, mild reaction conditions, and The advantage of high glucose conversion rate, but after the catalyst used is recycled for a certain number of times, the catalytic efficiency decreases, so that the glucose conversion rate is reduced, the reaction time is prolonged, or even has no catalytic activity. The catalyst must be scrapped and updated, and the catalyst consumption per unit product is correspondingly increased. It also makes the production cost of sodium gluconate products higher, and because the waste catalyst contains precious metal palladium, its storage and rational utilization are more important; the electrolytic oxidation method is currently a more researched method and has a certain comprehensive cost advantage, but due to technology The reason for this is that most of the domestic are still in the laboratory research stage and have not formed an industrial scale. Therefore, the catalytic oxidation method is currently the main method for the production of sodium gluconate in China, and its output accounts for more than 80%.
The catalyst used in the catalytic oxidation method of sodium gluconate is an activated carbon carrier catalyst containing 5% Pd. When preparing the catalyst, the palladium must be converted into palladium chloride and dissolved in the solution to be adsorbed by the activated carbon carrier, or directly adsorbed by the activated carbon with palladium chloride, and then used The reducing agent reduces the palladium ions adsorbed on the carrier into metal palladium particles with selective catalytic activity, which are uniformly loaded on the activated carbon. The amount of Pd/C catalyst used in the production of sodium gluconate by catalytic oxidation is 1% to 2% of sugar. Based on the annual output of 1000 tons of sodium gluconate production device, the annual Pd/C catalyst needs to be scrapped about 550-600kg, which is approximately equivalent to pure palladium. At 30kg, the price of metal palladium has been as high as 50 yuan/g for a long time. Therefore, the recovery and secondary utilization of palladium have important practical significance for reducing the production cost of sodium gluconate.
Bailin Gorup Co., Ltd. mainly produces Sodium gluconate. For details, please click: www.bailincorp.com